Zvast Biotechnology
Dental Implant
The Beagle Dental Implant Model is a standardized SCI-recognized large-animal model in translational implant dentistry, implant osseointegration, alveolar bone augmentation and peri-implant lesion research. Standardized alveolar sockets are established via surgical extraction of posterior teeth in Beagle dogs, and commercial standardized dental implants are implanted in immediate or delayed modes to construct three classic research systems: normal implant osseointegration model, peri-implant critical bone defect augmentation model, and peri-implantitis pathological model. Relying on the highly homologous biological characteristics of Beagle jaw anatomy, alveolar bone metabolism, periodontal soft and hard tissue complex, and occlusal loading pattern with humans, this model faithfully recapitulates real clinical scenarios including routine dental implantation, pre-implant bone augmentation, peri-implant bone defect repair, and the pathogenesis and repair of peri-implantitis. Compared with small rodent models, Beagle dogs possess sufficient alveolar bone thickness, consistent cortical-cancellous bone ratio, bone remodeling turnover rate, and implant-bone interface integration mechanism with humans, which truly reproduce the whole process of physiological implant loading, bone remodeling, material degradation and osseointegration. The intra-animal control design with bilateral symmetric jaw implantation sites minimizes individual variation with low experimental dispersion and high reproducibility, fully meeting the experimental standard requirements of high-impact dental SCI journals, National Natural Science Foundation projects, and postgraduate dissertations. This model is widely adopted for preclinical efficacy and biosafety evaluation of novel implant surface modification technologies, implant coating materials, GBR barrier membranes, bone graft substitutes, peri-implant anti-inflammatory agents, osseointegration-promoting stem cell preparations, and peri-implant tissue regeneration strategies.
Immediate postoperative CBCT confirms accurate implant position, depth and angle without intraoperative bone fracture, alveolar fracture or implant deviation. The peri-implant defect model shows localized bone defect cavities with clear boundaries, and the defect size has no significant deviation from the preset standard. Imaging results at each postoperative follow-up time point show that the peri-implant defects in the blank defect control group cannot achieve complete spontaneous osseous healing with persistent bone loss in the defect area; no implant loosening, displacement or shedding occurs in all groups, and no obvious pathological bone resorption, extensive osteonecrosis or inflammatory bone destruction around implants is observed. Fulfillment of the above criteria confirms the successful establishment of the Beagle dental implant model with excellent stability, which can accurately distinguish the differences in osteogenic, osseointegrative and bone repair efficacy of materials and interventions among groups.
The defect area around implants in the blank defect control group is mainly filled with fibrous connective tissue, and newly formed bone tissue is only limited to the defect edge without complete and continuous bone bridging covering the implant surface. Core histomorphometric indexes: bone volume fraction (BV/TV), bone-implant contact rate (BIC) and proportion of newly formed bone area are significantly lower than those in the positive intervention group; osteoclast number and fibrous tissue proportion are significantly higher than those in the repair group. No extensive non-specific inflammatory infiltration, foreign body giant cell aggregation or persistent chronic inflammation is observed in all modeled specimens, indicating controllable surgical trauma and stable model interference factors, and the experimental data meet SCI-level credibility standards.
The core evaluation criteria for the standardized dental implant model are as follows: implants achieve stable primary retention and complete progressive osseointegration after surgery; peri-implant critical bone defects possess the critical biological property of "inability to achieve complete spontaneous osseous healing", which effectively avoids the masking effect of autologous bone repair on experimental results. The alveolar bone remodeling pattern and implant-bone interface healing mechanism of Beagle dogs are highly consistent with human clinical implantation, which truly simulates the pathological and repair processes of poor clinical implant osseointegration, peri-implant bone defects and bone augmentation repair. This model can objectively and quantitatively evaluate the regulatory effects of various biomaterials, active factors and modification technologies on implant osseointegration and bone defect regeneration, serving as the gold-standard basis for model reliability recognized in translational implant dentistry.
The Beagle dental implant model is the mainstream large-animal model for high-impact SCI papers in the fields of implant dentistry, bone tissue engineering and dental biomaterials. The bilateral intra-animal control design greatly reduces individual experimental error and animal consumption, complying with animal ethical requirements. The alveolar bone anatomy, bone metabolism, implant healing mechanism and occlusal loading pattern of Beagle dogs are highly homologous to humans, with far superior translational value compared with rodent models. It is compatible with three classic research directions including normal osseointegration, bone defect augmentation and peri-implant lesions with excellent model compatibility. The surgical procedure is standardized with quantifiable parameters and high repeatability. Multiple non-invasive in vivo CBCT follow-ups are supported, and multi-dimensional detections including Micro-CT, histology, molecular biology and implant stability can be completed simultaneously at the endpoint to form a complete closed-loop data chain. The experimental results are highly recognized and easily accepted by authoritative SCI journals in stomatology, biomaterials and prosthetic implantology, adapting to the research system of national and provincial natural science projects and postgraduate dissertations.
The Beagle Dental Implant Model is mainly used to systematically elucidate the complete temporal mechanism of implant surface osseointegration, peri-implant clot organization, angiogenesis, osteoblast recruitment and differentiation, bone defect regeneration, bone remodeling and peri-implant soft tissue attachment. It accurately evaluates the in vivo osteogenic capacity, osseointegration efficacy, biocompatibility and long-term stability of various implant surface modification technologies, functional coatings, bone graft substitutes, absorbable GBR barrier membranes, sustained drug delivery systems and stem cell composite repair materials. It explores the material-bone interface interaction, anti-inflammatory regulation and osteoclast balance mechanism in the oral microenvironment, and supports preclinical safety and efficacy verification of novel dental implant materials and bone augmentation repair strategies. As a core standardized large-animal model in implant regenerative medicine, translational dental biomaterial research and implant repair mechanism exploration, it fully adapts to all scientific research scenarios including project proposal, fund application, SCI paper publication and dissertation writing.
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