Zvast Biotechnology
Pharmacokinetics (PK) primarily studies the patterns of drug concentration changes in the body over time, involving aspects such as ADME, which refers to the processes of drug Absorption, Distribution, Metabolism, and Excretion in the body. ADME determines the bioavailability of the drug in the body, the duration of its action, and the required dosage.
About Pharmacokinetics
Studying pharmacokinetics can determine the dose and interval between drugs, as well as determine whether the drug can achieve safe and effective concentrations at the corresponding site of action. In the process of innovative drug development, pharmacokinetic research is in the same important position as pharmacodynamics research and toxicological research, and has become an important part of drug preclinical research and clinical research.
Zvast Biopharmacokinetics Service Team has solid theoretical knowledge and rich experience in preclinical research implementation, and can provide customers with high-quality and efficient in vitro research, in vivo research, and biological sample analysis services.
Service Items
» Metabolic stability (microsomes/hepatocytes/S9/plasma/whole blood/gastrointestinal fluids)
» Permeability (Caco-2/MDCK/PAMPA)
» Plasma protein binding (plasma/tissue, etc.)
» CYP450 enzyme metabolism phenotype (liver microsomes/recombinant enzymes)
» CYP450 enzyme inhibition (including TDI)
» CYP450 enzyme induction
» Red blood cell/plasma distribution ratio
» Metabolite identification (liver microsomes/hepatocytes/recombinant enzymes/in vivo biological matrices)
» Solubility (kinetic/thermodynamic)
» Log D
» Animal dosing absorption
» Animal dosing tissue distribution/blood-brain barrier
» Mass balance/excretion
» PK druggability screening (cassette dosing, rapid PK)
» Large molecule bioanalytical assays, immunogenicity testing
» Small molecule bioanalytical assays
» Bioanalytical method development/transfer/validation, etc.
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