Zvast Biotechnology
Periodontitis
The thread is ligated at the cervical neck of the canine.
Beagle periodontitis model is a classic large‑animal pre‑clinical model for simulating human chronic periodontitis. By combining mechanical ligature irritation and local microbial accumulation, plaque and biofilm rapidly accumulate around cervical region of teeth, triggering host inflammatory immune response. Progressive destruction of periodontal ligament, gingival recession, deep periodontal pocket and alveolar bone loss can be reproduced, which is suitable for evaluating periodontal regeneration materials, drug efficacy and periodontal surgical intervention strategies.
(1) Clinical performance: obvious gingival redness and swelling, gingival bleeding on probing, plaque massive accumulation, probing depth ≥4 mm, clinical attachment loss ≥2 mm;
(2) Imaging index: intra‑oral X‑ray or Micro‑CT shows horizontal or vertical alveolar bone resorption, alveolar bone height reduction ≥20% compared with baseline;
(3) Histopathological criterion: gingival inflammatory cell infiltration, periodontal ligament fiber disorder and destruction, alveolar bone osteoclast activation and bone resorption lacuna formation, inflammatory infiltration in periodontal pocket. The model is considered successfully established when clinical manifestations combined with imaging indexes are satisfied.
Advantages: Beagle oral anatomical structure is highly similar to human periodontal tissue; ligature‑induced periodontitis has high success rate, good reproducibility, short modeling cycle; it can simulate chronic progressive periodontitis process, suitable for periodontal regeneration biomaterial, drug, periodontal surgery translational research. Limitations: Ligature‑triggered periodontitis belongs to aggravated induced lesion, which is not completely identical to human spontaneous chronic periodontitis; individual difference of inflammatory response exists among experimental animals; regular monitoring of ligature shedding is required during experiment; high raising cost of large animal model.
Pre‑clinical efficacy evaluation of periodontal regenerative biomaterials; in‑vivo validation of local anti‑periodontitis drugs; efficacy assessment of guided tissue regeneration(GTR) and guided bone regeneration(GBR) surgical techniques; mechanism research of periodontal inflammation‑bone destruction axis; safety and effectiveness verification of new dental implant under periodontitis background.
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