Zvast Biotechnology
Pancreatic Cancer
HCT-116 is a widely used human colorectal carcinoma cell line originating from primary human colon carcinoma tissue. This cell line possesses rapid proliferation capacity, moderate invasiveness and well-characterized molecular features including microsatellite instability (MSI). The subcutaneous xenograft mouse model established with HCT-116 cells is a standard preclinical in vivo model for colorectal cancer research, extensively applied in anti-tumor drug screening, targeted therapy evaluation, chemoresistance research and nanoparticle drug delivery system validation. This model features stable tumor formation, predictable growth kinetics and convenient real-time tumor volume measurement, suitable for large-scale in vivo pharmacodynamic screening of anti-colorectal cancer agents.
Immunodeficient mice lack mature T lymphocytes and cannot generate effective immune rejection against human-derived tumor cells. After harvesting HCT-116 cells in logarithmic growth phase and preparing cell suspension, the suspension is subcutaneously inoculated into the dorsal flank of immunodeficient mice. Tumor cells continuously proliferate in subcutaneous tissue and eventually form solid tumor masses. Regular recording of tumor volume, body weight and survival status of mice enables assessment of in vivo tumor growth kinetics and quantitative analysis of anti-tumor efficacy of test compounds or biological agents.
We're here to help! Whether you have questions about our products, need support, or want to share feedback, we'd love to hear from you. Please reach out through any of the methods below, and our team will get back to you as soon as possible.
