Zvast Biotechnology
Cervical Cancer
HeLa is a classic human cervical adenocarcinoma cell line derived from human cervical cancer tissue, which is one of the most widely used immortalized cell lines in biomedical research. The cell line exhibits strong proliferation capacity, stable passage characteristics and high tumorigenicity in immunodeficient animals. The subcutaneous xenograft mouse model established with HeLa cells serves as a standard preclinical in vivo model for cervical cancer research, widely applied in anti-tumor drug screening, targeted therapy evaluation, tumor biological mechanism exploration and nanoparticle delivery system validation. The model features rapid and stable tumor formation, simple manipulation and convenient real-time tumor volume measurement, suitable for large-scale in vivo pharmacodynamic screening of anti-cervical cancer agents.
Immunodeficient mice lack mature T lymphocytes and cannot generate effective immune rejection against human-derived tumor cells. After harvesting HeLa cells in logarithmic growth phase and preparing cell suspension, the suspension is subcutaneously inoculated into the dorsal flank of immunodeficient mice. Tumor cells continuously proliferate in subcutaneous tissue and eventually form solid tumor masses. Regular recording of tumor volume, body weight and survival status of mice enables assessment of in vivo tumor growth kinetics and quantitative analysis of anti-tumor efficacy of test compounds or biological agents.
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