Zvast Biotechnology
| System | Drugs | Induce cell differentiation or lesion or simulate disease | Cell Line |
| Metabolism | Glucose | Diabetic Wound | Adipose-derived mesenchymal stem cells, human keratinocyte cell line (Hacat), immortalized human umbilical vein endothelial cell line (HUVEC) |
| Metabolism | IBMX | Obesity | 3T3-L1 preadipocytes |
| Metabolism | IBMX | Obesity | 3T3-L1 preadipocytes |
| Metabolism | Dexamethasone, Insulin, IBMX | Obesity | Mouse embryonic fibroblasts (preadipocytes) 3T3-L1 |
| Metabolism | Insulin | Diabetes | Human hepatocellular carcinoma cell line HepG2 cells |
| Metabolism | PMA phorbol ester, Palmitic acid | Atherosclerosis (AS) | THP-1 cells |
| Metabolism | TNF-α, Glucose, FFA, IL-6 | Obesity | Preadipocytes HPA-v |
| Metabolism | Sodium oleate (H7VEF-KK, TCI); Sodium palmitate | Abnormal Glucose and Lipid Metabolism Cell Model | Human hepatocellular carcinoma HepG2 cells |
| Metabolism | OA+PA | Non-Alcoholic Fatty Liver | Mouse liver cells AML12 cells |
| Metabolism | Ethanol | Liver Injury | Mouse liver cell line AML12 |
| Metabolism | Stearic acid | Diabetes | Mouse pancreatic beta cell line Beta-TC-6 |
| Respiration | LPS | Ferroptosis | A549 human lung epithelial cells |
| Respiration | LPS | Chronic Obstructive Pulmonary Disease (COPD) | Mouse bronchial smooth muscle cells |
| Respiration | hrFABP4 | Metabolic Inflammation Model Related to Endothelial Dysfunction | Human umbilical vein endothelial cells (HUVEC cells) |
| Respiration | Nerve Growth Factor (NGF) | Asthma | Bronchial epithelial cells BEAS-2B |
| Anti-inflammatory | LPS | Early AKI Inflammatory Injury | Bone marrow-derived macrophages (BMDMs)/THP-1 cells, Jurkat cells |
| Anti-inflammatory | LPS (inducing mature DC cells) | Immune Rejection Reaction | Rat dendritic cells (DC) |
| Anti-inflammatory | LPS | Inflammation | Mouse monocyte/macrophage leukemia cell line RAW264.7 cells |
| Anti-inflammatory | / | Induced Differentiation into Unpolarized Macrophages (UaM) | Human umbilical cord blood-derived mesenchymal stem cells UCB-MSC and human monocytes THP-1 |
| Anti-inflammatory | Nrf2 inhibitor ML385 | Macrophage Inflammation | RAW264.7 mouse monocyte/macrophage |
| Anti-inflammatory | PMA phorbol ester | Effect of Human Chorionic Villus Membrane Supernatant on Macrophage Polarization | Human extravillous trophoblast cell line HTR-8-Svneo; human monocyte cell line THP-1 |
| Anti-inflammatory | PMA phorbol ester, LPS | THP-1 Macrophage Inflammation Model | Human monocyte cell line THP-1, vascular endothelial cells |
| Anti-inflammatory | PMA phorbol ester | THP-1 Macrophage Inflammation Model | THP-1; NCM460 |
| Anti-inflammatory | PMA phorbol ester | Neutrophilic Inflammation | Neutrophils |
| Anti-inflammatory | IL-4 | Inflammation | Spleen lymphocytes SPL |
| Anti-inflammatory | PMA phorbol ester, LPS | Macrophage Polarization | Human normal lung epithelial cells BEAS-2B, THP-1 cells |
| Anti-inflammatory | PMA phorbol ester | Macrophage Polarization | Human monocyte cell line THP-1 |
| Urinary | Hypoxia | Kidney Injury | HK-2 human renal proximal tubular epithelial cells |
| Urinary | / | Systemic Lupus Erythematosus (SLE) | Human peripheral blood mononuclear cells PBMC |
| Urinary | TGF-β1 | Mdivi-1 can significantly prevent mitochondrial membrane depolarization induced by staurosporine treatment, reducing cell damage | Human peritoneal mesothelial cells HMrSV5 |
| Urinary | Resveratrol | Inhibition of Pyroptosis | Mouse renal podocytes MPC-5 |
| Urinary | Angiotensin 2 | Chronic Kidney Disease (CKD) | HK-2 (human renal proximal tubular epithelial cells) |
| Facial | Chlorogenic acid | Dry Eye Syndrome | Rat lacrimal gland epithelial cells |
| Skin | No modeling drug | Effect of Wnt and TGF-β/BMP Signaling Pathway Inhibitors on Co-Cultured Hair Follicle Outer Root Sheath Cells | tSKP dermal fibroblasts |
| Nervous | LPS | Sepsis | Rat glial cells |
| Nervous | Glucose-oxygen deprivation | Iron Death After Cerebral Ischemia | Mouse hippocampal neuron cell line (HT22) |
| Nervous | Glucose-oxygen deprivation (OGD) and Hemin combined treatment | Cerebral Hemorrhage | Human brain microvascular endothelial cells (hCMEC/D3) |
| Nervous | LPS | Postoperative Cognitive Dysfunction | BV2 mouse microglial cells |
| Nervous | 6-OHDA | Parkinson's Disease | Rat adrenal chromaffin cell tumor cell line PC12 cells |
| Nervous | 6-OHDA | Parkinson's Disease | Human neuroblastoma cell line SH-SY5Y |
| Nervous | / | Oxygen-Glucose Deprivation | Primary isolated rat astrocytes (ASTs)\nPrimary isolated rat oligodendrocyte precursor cells (OPC) |
| Nervous | D-Galactose | Aging Model | Bone marrow mesenchymal stem cells |
| Nervous | Recombinant Mouse IL-2 (carrier-free) | Autoimmune Encephalomyelitis | CD4+ T cells |
| Nervous | / | Oxygen-Glucose Deprivation/Reoxygenation (OGD/R) Model | Rat pheochromocytoma cell line PC12 |
| Nervous | Hemin (Synonyms: Hematin) | In Vitro Cerebral Hemorrhage (ICH) Model | Mouse neuronal cells HT22 |
| Nervous | MK801(HY-15084/cs-1209) | Schizophrenia-Induced Osteoporosis | Mesenchymal cells |
| Nervous | Chlorogenic acid | Oxygen-Glucose Deprivation/Reoxygenation (OGD/R) Model | |
| Nervous | LPS | Postoperative Delirium | Mouse microglial cells BV2 |
| Reproductive | MG132 | / | Trophoblast cells HTR-8/Svneo |
| Reproductive | Dexamethasone, Insulin | Polycystic Ovary Syndrome (PCOS) | Ovarian granulosa cells GC |
| Reproductive | h-IL-33 | Endometriosis | Human endometrial stromal cells\n(ESCs) |
| Five senses | LPS | Induced Inflammation | Human periodontal ligament fibroblasts\n(PLFs) |
| Five senses | VEGF | VEGF Gene Induces Vascular Generation in OSF Tissue | Human oral mucosal fibroblasts |
| Five senses | H2O2 | Presbycusis | Mouse cochlear hair cells HEI-OC1 |
| Five senses | 1,25-(OH)2D3 | Periodontitis | Human primary periodontal ligament fibroblasts |
| Five senses | / | Retinal Ischemia-Reperfusion Injury | ARPE-19 human retinal pigment epithelial cells |
| Digestive | LPS | Gastritis | Rat gastric mucosal epithelial cells |
| Digestive | LPS | Intestinal Barrier Injury | Caco-2 human colorectal adenocarcinoma cells |
| Digestive | LPS | Sepsis | Mouse intestinal stromal cells - immortalized |
| Digestive | Palmitic acid (Synonyms) | Pancreatitis | AR42J rat pancreatic exocrine cells |
| Digestive | Deoxycholic acid | Gastroesophageal Reflux | Rat gastrointestinal interstitial cells of Cajal (ICC) |
| Digestive | Isoniazid | Hepatocyte Injury | Human hepatocyte cell line QSG-7701 |
| Digestive | LPS, Rapamycin | LPS-induced; Rapamycin-induced Autophagy | Rat small intestinal epithelial cell line (6th passage) (IEC-6) |
| Digestive | Taurodeoxycholic acid | Hepatobiliary Fibrosis | Human intrahepatic bile duct epithelial cells |
| Digestive | Sophoridine | Functional Diarrhea Model | Colon epithelial cells Caco-2 cells |
| Digestive | Sodium taurocholate | Acute Pancreatitis | Rat pancreatic exocrine cells AR42J cells |
| Digestive | Sodium taurodeoxycholate | Hepatobiliary Fibrosis | Human intrahepatic bile duct epithelial cells |
| Cardiovascular | LPS | Sepsis | Rat cardiomyocytes H9c2 |
| Cardiovascular | LPS | Sepsis Coagulation Disorder | Human microvascular endothelial cells HMEC-1 |
| Cardiovascular | NaHS | Myocardial Ischemia Reperfusion Myocardial Cell Ischemia | Rat cardiomyocytes H9C2 |
| Cardiovascular | Angiotensin II | Cardiac Hypertrophy | Rat cardiomyocytes\n(H9C2 cells) |
| Cardiovascular | Cadmium chloride | Atherosclerosis (AS) | Endothelial cells |
| Cardiovascular | Doxylamine hydrochloride | Myocardial Hypertrophy | Primary cardiomyocytes |
| Cardiovascular | LPS | Hypertension | Primary rat aortic smooth muscle cells |
| Cardiovascular | ox-LDL, PMA | Atherosclerosis (AS) | Human acute monocytic leukemia cells THP-1 |
| Cardiovascular | Erastin | Atherosclerosis | Human umbilical vein cell fusion cells\n(EA.hy926 cells) |
| Cardiovascular | PMA phorbol ester | Deep Vein Thrombosis | Mouse bone marrow-derived neutrophils, c66 mouse vascular endothelial cells |
| Cardiovascular | Hypoxia and glucose deprivation | Myocardial Infarction | Mouse monocytic leukemia cells RAW264.7, mouse primary cardiomyocytes |
| Cardiovascular | Doxorubicin | Heart Failure | Cardiomyocytes H9C2 |
| Cardiovascular | Angiotensin II | Hypertension Model | Mouse aortic vascular smooth muscle cells |
| Cardiovascular | Chloroquine | Hypoxia-induced | Human leukemia cell lines HL-60 and MOLM-13 cells |
| Cardiovascular | Ferroptosis inducer\nErastin | Myocardial Fibrosis Atrial Fibrillation Model | Mouse cardiac fibroblasts |
| Cardiovascular | Angiotensin II | Endothelial Cell Injury | HUVEC cells |
| Motor | TNF-α | Sarcopenia | C2C12 mouse myoblasts |
| Motor | LPS | Lumbar Intervertebral Disc Degeneration | Rat nucleus pulposus cells |
| Motor | / | Arthritis | Rat chondrocytes |
| Motor | High glucose | Inhibition of Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells | Mouse bone marrow mesenchymal stem cells |
| Motor | TNF-α | Rheumatoid Arthritis | RA-FLSs Rheumatoid Arthritis fibroblast-like synovial cells |
| Motor | RANKL nuclear factor-κB ligand receptor activator | Osteoporosis | RAW264.7 mouse monocytic leukemia cells, osteoclasts |
| Motor | MCSF, RANKL | Chronic Osteomyelitis | RAW264.7 cells |
| Motor | Dexamethasone | Osteoporosis | Immortalized human osteoblast cells |
| Motor | RANKL | Osteoporosis | Osteoblast cell line hFob1.19, monocytic cell line RAW264.7 |
| Motor | None | Osteogenic Differentiation | Primary rat osteoblast isolation |
| Motor | Hypoxia | Vertebral Endplate Chondrocyte Injury | Rat bone marrow-derived BMSCs, rat vertebral endplate chondrocytes |
| Tumor | LPS | Macrophage Infiltration in Nasopharyngeal Carcinoma Tumor Microenvironment | M1 macrophages |
| Tumor | / | Glioma | Glioma cells (U251 and U87) |
| Tumor | Worenine (Methyl coptisine) | Glioma | Human brain astrocytoma U87MG cells |
| Tumor | / | Ovarian Cancer | Human ovarian cancer SKOV-3 and OVCAR3 cells |
| Tumor | / | Hepatocellular Carcinoma | Human normal liver cell line (THLE-2) Human hepatocellular carcinoma cell lines (HCC cells) HuH7, MHCC-97H, HCCLM3, Hep-3B |
| Tumor | MG132 | Lung Cancer | Human lung cancer cell line PC-9 |
| Tumor | / | Liver Cancer | Human hepatocellular carcinoma cells HuH7 |
| Tumor | PMA phorbol ester | Colorectal Cancer | Human colorectal adenocarcinoma cells HT29; SW620 |
| Tumor | Serine-deficient medium | Liver Cancer | Liver cancer cells |
| Tumor | / | Resveratrol Inhibits Lung Adenocarcinoma A549 Cells | Human lung adenocarcinoma cells A549 |
| Tumor | Dexamethasone | Prostate Cancer | GM12878 human B lymphocytes; LNCaP clone FGC human prostate cancer cells |
| Tumor | / | Esophageal Cancer | Human esophageal cancer cell line TE-1 |
| Tumor | Rapamycin | Nasopharyngeal Carcinoma | Nasopharyngeal carcinoma cells NPC/HK-1 |
| Tumor | Sodium acetate | Intestinal Cancer | Human colorectal adenocarcinoma cells Caco-2 |
| Tumor | Chlorogenic acid | Non-small Cell Lung Cancer | A549 |
| Tumor | / | Oral Squamous Cell Carcinoma | Human oral squamous carcinoma cell line SCC-9 |
| Tumor | / | Lung Cancer | Lung cancer cell lines A549, Calu-1, H1975, H1299 |
| Tumor | / | Cervical Cancer | Hela/DDP cells |
| Tumor | / | Liver Cancer | Human hepatocellular carcinoma cell line (MHCC97-H) |
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