Scleroderma is a chronic connective tissue disease characterized mainly by systemic organ vasculitis and fibrosis, leading to hardening of the skin and internal organs. The disease can be classified into localized scleroderma and systemic sclerosis (SSc), the latter of which can be further divided into limited and diffuse types. Scleroderma commonly occurs in women aged 30 to 50, with a male-to-female ratio of 1:3 to 1:7. It is one of the connective tissue diseases with the highest mortality rate and currently has no specific cure, with treatment primarily focused on symptom management.